Abstract: Epilepsy is a common debilitating condition affecting children. Mindfulness intervention enhances mothers' self control in response to the quality of life of their children. Aim: The study aimed to evaluate mindfulness based program effectiveness for mothers of children with epileptic fits. Method: A quasi-experimental research design (one group pre/post/and follow up) was used. Settings: The study was conducted in epilepsy out-patient clinic at both Fayoum General Hospital and Mostafa Hassan Pediatric Hospital. Sampling: A non-probability purposive sample involved (120) mothers and their children who attended to the aforementioned settings. Tools: Four tools were used, 1st Tool: A structured interview questionnaire to assess mothers' knowledge regarding epilepsy.2nd Tool: Mothers' reported practices to assess mothers' practices before, during, and after epileptic fits as well as first-aids practices for their children.3rd Tool: Mindfulness Attention Awareness Scale 4th Tool: Pediatric Quality of Life Epilepsy Scale. Results: The epileptic children's quality of life, as well as the knowledge, and practices of the studied mother showed a highly statistically significant improvement at pre, post, and follow up implementation of mindfulness program with (P- value ˂0.001). Conclusion: There was a positive correlation between mothers' total knowledge, total practices, total mindful attention awareness, as well as total quality of life score of their children with epilepsy pre/post and follow up implementation of mindfulness program (p=<0.001). The research findings support the research hypothesis. Recommendation: Frequent mindfulness training program for mothers with epileptic children have utility to improve attentional self-regulation and children quality of life.