Background: In the modern diet, high fructose corn syrup (HFCS) is a common sweetener, especially in processed foods and drinks. Even though HFCS is widely used. Worries about its potential health risks have been grown recently. Objective: This review article aimed to give a thorough grasp of the health hazards associated with HFCS. Methods: We searched Google Scholar, Science Direct, PubMed and other online databases for Health Hazards of High Fructose Corn Syrup Consumption. The author also reviewed references from pertinent literature, however only the most recent or comprehensive studies from 2015 to 2023 concentrating on the metabolic, cardiovascular, hepatic and gastrointestinal health impacts of HFCS were included. Documents in languages other than English were disqualified due to lack of translation-related sources. Papers such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations that were not part of larger scientific studies were excluded. Conclusion: High fructose corn syrup consumption is linked to significant threats to health. The main goals of public health campaigns should be to raise awareness of the possible hazards of HFCS and to decrease its use. Limiting its use in food goods through regulations may also be required to encourage the use of healthier substitutes. To better understand the long-term health impacts of HFCS especially in vulnerable groups, more research is required. Policymakers can create efficient plans to lessen the negative health effects of HFCS and consumers can make educated dietary choices by being aware of these hazards.