Introduction: The is study compared the effects of spinal and general anesthesia on changes in blood glucose concentrations during cesarean section in nondiabetic patients. Patients and methods: 40 pregnant women scheduled for the elective cesarean section at Babylon Hospital and Al Sadiq teaching hospital between 1^st of December ,2023 to 1 march 2024 . patients were electively allocated to two groups (S and G). Group S included patients who chose spinal anesthesia, and group G included patients who chose general anesthesia. Results: The results show there is a significant proportional increase in mean blood glucose concentrations with glucose-check timing (5 minutes before induction, 5 minutes after induction, 5 minutes before the end of surgery, and 30 minutes after the end of surgery), and this increase is significantly much greater in general anesthesia than it is in spinal anesthesia. Conclusion: The effect of general anesthesia on blood glucose concentrations was significantly greater than the effect of spinal anesthesia, which indicates that the hormonal stress response is much greater in general anesthesia than in spinal anesthesia.