Background: Urinary diversion through the ileal conduit is a common surgery. Assessing patients' knowledge and deficiencies in self-care practices might help meet their demands and enhance their outcome. Aim: Evaluating the effective of the nursing rehabilitation program on knowledge and self-care practice in Ileal conduit diversion patients. Method: A quasi-experimental study (pre–post test) design was utilized to fulfill the aim of the study. Setting: The study was carried out in the oncology surgery department& out-patients clinic at South Egypt Cancer Institute; on a purposive sample of 30 male and female adult patients undergoing ileal conduit urinary diversion. Two tools were utilized; (I): Patient structured interviewing questionnaire. (II): knowledge and self-care practice assessment. Results: The majority of ileal conduit patients were males, aged between 50 to less than 65 years, married, non-educated, and most worked in farming and from rural areas. Half (50%) of the patients had bladder cancer, while 40% suffered from hypertension. More than half (56.7%) had a right-side stoma, and 53.3% underwent radiotherapy. There was a statistically significant difference between immediately post, before discharge and after one month regarding total patient knowledge and stoma self-care practice (P. =0.000). Conclusion: Improvement of total knowledge and self- care practices in patients undergoing ileal conduit urinary diversion after application of the rehabilitation program. Recommendations: Further research is needed to explore the long-term effects and to identify the most effective educational strategies for improving nurses' knowledge, skills, and attitudes in this area.