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426963

Prevalence of HLA-DQ among Patients with H. Pylori and cytotoxic-associated gene (Cag A)

Article

Last updated: 11 May 2025

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: Helicobacter pylori is an important intestinal bacterium associated with gastritis, peptic ulcer disease, and gastric cancer. Antibodies produced against its cytotoxin-binding gene A (CagA) are protective. The host immunological response to H. pylori antigens may be significantly influenced by human leukocyte antigens. Objective: This study was designed to investigate the relation between HLA-DQ genotypes and H. pylori Methodology: One hundred fifty patients have H. pylori and one hundred healthy. H. pylori infection was determined by urea breath test (UBT). Serum concentrations of anti-Cag A IgG were analyzed by ELISA method and HLA-DQ genotypes were analyzed by SSP-PCR. Results: The study showed that patients aged 25-34 years were the most susceptible age group to H. pylori infection. Furthermore, the current study showed a higher incidence of H. pylori infection among females (63.33%), while 36.66% of males were infected with H. pylori. The current study also showed that approximately 72% (48%) of the total number of H. pylori patients were CagA positive (t = 45.00, p = 0.0001). Furthermore, the current study showed that when comparing H. pylori -positive patients with healthy controls, we detected a significantly higher frequency of the HLA-DQA1*05:01 allele (p = 0.0001). The prevalence of the HLA-DQB1*05:02 allele was also found to be not statistically significant in H. pylori patients compared to healthy individuals (P = 0.895). Conclusion: The study showed no significant correlation between the HLA-DQB1*0502 genotype and H. pylori infection; however, HLA-DQA1*0501 may make patients more susceptible to superficial gastritis.

DOI

10.21608/ejmm.2025.376163.1569

Keywords

HLA-DQA1, HLA-DQB1, H. pylori

Authors

First Name

ALAA

Last Name

DAHEWAL

MiddleName

H.

Affiliation

1Department of Microbiology, Collage of Medicine, University of Thi-Qar, Thi-Qar, 64001

Email

alaa-hm23-24@utq.edu.iq

City

-

Orcid

0009-0005-5611-4247

First Name

Faez

Last Name

Abdulmuhsen

MiddleName

K.

Affiliation

1Department of Microbiology, Collage of Medicine, University of Thi-Qar, Thi-Qar, 64001

Email

faez.kh@utq.edu.iq

City

-

Orcid

-

First Name

Taleb

Last Name

Ali

MiddleName

H.

Affiliation

Department of internal medicine, Collage of Medicine, University of Thi-Qar, Thi-Qar 64001

Email

taleb-h@utq.edu.iq

City

-

Orcid

-

Volume

34

Article Issue

3

Related Issue

53640

Issue Date

2025-07-01

Receive Date

2025-04-17

Publish Date

2025-07-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_426963.html

Detail API

http://journals.ekb.eg?_action=service&article_code=426963

Order

426,963

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Prevalence of HLA-DQ among Patients with H. Pylori and cytotoxic-associated gene (Cag A)

Details

Type

Article

Created At

11 May 2025