Pughead deformity, characterized by craniofacial abnormalities resulting in a shortened and blunt snout, is a significant developmental anomaly observed in wild and cultured fish populations. This condition arises from multifactorial influences, including genetic predispositions, environmental stressors, nutritional deficiencies, and anthropogenic factors. The deformity is marked by abnormal bone structure, often manifesting as a steep, protruding forehead. While pughead deformity has been documented in numerous fish species, Nemipterus japonicus remains notably absent from scientific reports. However, pugheaded specimens have been identified in the Red Sea, specifically in the Suez Canal and Hurghada regions. Elevated deformity rates in this area have prompted investigations into potential causative factors, including hypoxia, contamination, and genetic defects, emphasizing the need for targeted research and management interventions.