Nanotechnology is widely used nowadays in the medical and dental fields, it includes particles whom size is ranging from (1-100 nm), known as nanoparticles. The small particle size of these nanoparticles and their high surface area to volume ratio is the reason behind superior physical, mechanical, and biological properties. Metal and metal oxide nanoparticles become the research hotspot of the dental field. Cerium Oxide Nanoparticles (CeO₂NPs) are one of the metal oxide nanoparticles that have gotten a great attention during recent years owing to its superior properties. It exhibited redox potential, antibacterial activity, biofilm suppression and anti-inflammatory potential. Cerium oxide nanoparticles (CeO₂NPs) showed reduced toxicity to cells and unique antibacterial mechanism. In addition, Cerium Oxide Nanoparticles have superior scavenging abilities for the Reactive Oxygen Species (ROS), so they are recommended for different therapeutic applications. This review will present some applications of Cerium Oxide Nanoparticles in the dental field, such as the antimicrobial activity, dental caries prevention, modifications in dental materials, dental implant coating, tissue engineering, periodontal therapy and root canal disinfection.