Background: Hyaluronic acid has an important role in skin
viscoelasticity.
Objective: The present study was performed to evaluate
The effect of injecting the non-cross-linked hyaluronic acid with
growth factors and/or hyper-diluted calcium hydroxyapatite for
treating facial skin pigmentations and face rejuvenation, including
texture, elasticity, and firmness through collagen induction.
Methods: 30 female patients who suffered from dry skin
with pigmentations, were included in the study. All patients
were randomly divided into three groups; the first group was
injected with non-cross-linked hyaluronic acid with growth factors,
And the second group was injected with hyper-diluted calcium
hydroxyapatite filler, while the third group was injected
with a hybrid mixture of non-cross-linked hyaluronic acid with
growth factors and hyper-diluted calcium hydroxyapatite filler.
Digital pictures were taken before the injection and immediately
After the injection for assessment of the clinical results
as well as during the follow-up periods (2 weeks, 1 month &
3 months).
Results: The third group showed a marked reduction in
The amount of skin pigmentation at 2 weeks after injection
along with improvement in the skin texture and elasticity, those
Changes remained stable up to three months after treatment.
Conclusion: The use of a hybrid mixture of non-cross
linked hyaluronic acid with growth factors & calcium hydroxyapatite
Filler provides a marked reduction in the amount
of facial pigmentations and provides a better skin texture than
The use of each product alone.