375787

Comparative study of alcohol clove extract, TiO2 nanoparticles, and clove extract-TiO2 complex in controlling bacterial growth in burn infections

Article

Last updated: 04 May 2025

Subjects

-

Tags

Antimicrobial resistance

Abstract

Background:  Individuals with burn injuries (BI) are particularly vulnerable to infections. Microbial infection led to morbidity and mortality.  This study explores the frequencies of bacteria associated with BI-infection and detects which one is the highly prevalent species. Also, it detects the microbial activity of three kinds of antimicrobial agents involved: alcohol clove extract. TiO2 nanoparticles; and clove extract mediated by TiO2NP. This study enrolled seventy swabs collected from BI-patients.  Methods: We used routine methods and the VITECK assay to detect bacteria. The dilution microplate assay was used to detect the minimum inhibitory concentration (MIC) for all agents. Results of study revealed that VMRSA had a high frequency score of 42.9%, followed by MARSA and pseudomonas aeruginosa at 14.3%. According to microbial activity, clove extract was revealed to have the lowest concentration inhibition growth bacterium at 0.75 mg/ml; additionally, concentration 1.55 mg/ml for TiO2NPs had been virtue inhibition growth bacteria; and also, it had the lowest dilution used as MIC. Furthermore, at a concentration of 0.75 mg/ml, clove extract mediated by TiO2NPs has a significant microbial activity to inhibit the growth of VMRSA more than a single agent microbial. Conclusion: Our finding found that VMRSA is a high-frequency bacterium and also a common bacteria associated with infection-burn injuries in patients. Finally, the clove extract mediated by TiO2NPs at a concentration of 0.75 mg/ml can be considered the MIC for VMRSA. Also, it can be suggested as a potential application in medical felids due to their forceful antimicrobial activity.

DOI

10.21608/mid.2024.309810.2131

Keywords

Clove Extract, TiO2NPs, Staphylococcus aureus, burn injure patients

Authors

First Name

Linda

Last Name

Khalaf Kenawe

MiddleName

-

Affiliation

Branch of Biology, Department of Science, College of Basic Education, Wasit University, Wasit, Iraq

Email

lknawi@uowasit.edu.iq

City

-

Orcid

-

First Name

Ruaa Salam

Last Name

Abbas

MiddleName

-

Affiliation

Branch of Biology, Department of Science, College of Basic Education, Wasit University, Wasit, Iraq

Email

rouaasalam266@gmail.com

City

-

Orcid

-

First Name

Ali Saad

Last Name

Kadhim

MiddleName

-

Affiliation

Branch of Biology, Department of Science, College of Basic Education, Wasit University, Wasit, Iraq

Email

alisaad@uowasit.edu.iq

City

-

Orcid

-

Volume

6

Article Issue

2

Related Issue

55370

Issue Date

2025-05-01

Receive Date

2024-08-04

Publish Date

2025-05-01

Page Start

680

Page End

688

Print ISSN

2682-4132

Online ISSN

2682-4140

Link

https://mid.journals.ekb.eg/article_375787.html

Detail API

http://journals.ekb.eg?_action=service&article_code=375787

Order

375,787

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Comparative study of alcohol clove extract, TiO2 nanoparticles, and clove extract-TiO2 complex in controlling bacterial growth in burn infections

Details

Type

Article

Created At

04 May 2025