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391082

The transfusion-transmitted infections overview, unveiling the novelist screening approaches

Article

Last updated: 04 May 2025

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Subjects

-

Tags

Infectious diseases

Abstract

Background: Transfusion-transmitted infections (TTIs) are defined as any bacterial, viral, or parasitic pathogen that can be transmitted through whole blood, platelets, or RBCs infusions to recipients for any medical or health conditions such as traumas, cancer diseases, or emergency cases. There are many medical and health problems attributed to the TTIs occurrence. Life threatening viruses that can be transmitted by transfusion such as HIV, HBV, and cytomegaloviruses (CMV). The data search in this review was carried out using different search engine such as Web of Science, Science Direct, Google Scholar, PubMed, and Scopus to find that many TTIs were previously detected among blood donors and in blood transmission of Treponema pallidum, HCV, HBV, or HIV, therefore, many screening approaches must be performed in blood banks to prevent, control, and decrease the incidence of these pathogen transmissions starting from enzyme-linked immunosorbent assay (ELISA),  nucleic acid amplification testing (NAT), or polymerase chain reactions (PCR) to reduce the risk of transmission these infections to people with or without symptoms of infections. Therefore,  this study aims to report, summarize, and unveil the most reported pathogens that can be transmitted through blood transfusion and the main screening approaches implemented by authorities and blood banks. Some regulations must be set by WHO to early screen blood donors and prevent the transmission of any pathogen to recipients.

DOI

10.21608/mid.2024.331428.2317

Keywords

Transfusion Transmitted Infections, TTIs, Screening

Authors

First Name

Akram

Last Name

Salah

MiddleName

N

Affiliation

Microbiology and Immunology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt

Email

akram.nader@pharma.asu.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdulkader

MiddleName

O

Affiliation

Microbiology and Immunology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt

Email

ahmed_osama@buc.edu.eg

City

-

Orcid

-

First Name

Hasnaa

Last Name

Gabr

MiddleName

Yasser

Affiliation

Biochemical and analysis department,, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt

Email

hasnayaser65@gmail.com

City

-

Orcid

-

First Name

Eman

Last Name

Elhefnawy

MiddleName

Magdy

Affiliation

Biochemical and analysis department,, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt

Email

em784159@gmail.com

City

-

Orcid

-

First Name

Shrouk

Last Name

Mohamed

MiddleName

Yasser

Affiliation

Biochemical and analysis department,, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt

Email

shroukeldahshan4@gmail.com

City

-

Orcid

-

First Name

Manar

Last Name

Abdulhady

MiddleName

Yasser

Affiliation

Biochemical and analysis department,, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt

Email

manaryasser981@gmail.com

City

-

Orcid

-

First Name

Mai

Last Name

Mohamed

MiddleName

Emad

Affiliation

Biochemical and analysis department,, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt

Email

maifroty2@gmail.com

City

-

Orcid

-

First Name

Shenouda

Last Name

Naguib

MiddleName

Harby

Affiliation

Biochemical and analysis department,, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt

Email

shenouda7arby@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Aleskandrany

MiddleName

Hasan

Affiliation

Biochemical and analysis department,, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt

Email

medoalexander100@gmail.com

City

-

Orcid

-

First Name

Eslam

Last Name

Goda

MiddleName

Mohamed

Affiliation

Biochemical and analysis department,, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt

Email

ez20192927@gmail.com

City

-

Orcid

-

First Name

Wagiha

Last Name

Elkalla

MiddleName

S

Affiliation

Microbiology and Immunology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt

Email

basma_elkalla@yahoo.com

City

-

Orcid

-

Volume

6

Article Issue

2

Related Issue

55370

Issue Date

2025-05-01

Receive Date

2024-10-26

Publish Date

2025-05-01

Page Start

588

Page End

602

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 6_Issue 2_Pages 588-602.pdf

PDF . 597.9kB

Link

https://mid.journals.ekb.eg/article_391082.html

Detail API

http://journals.ekb.eg?_action=service&article_code=391082

Order

391,082

Type

Review Article

Type Code

1,160

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

The transfusion-transmitted infections overview, unveiling the novelist screening approaches

Details

Type

Article

Created At

04 May 2025