Background: Perceived over-qualification occurs when people believe their work qualifications exceed their job demands, resulting in the ability to solve complex and risky problems creatively, becoming highly work-driven individuals, creating a subjective sense of deprivation, and eventually triggering negative emotions as work alienation. Aim: To investigate perceived over-qualification among nursing staff in relation to creative self-efficacy, workaholism, and work alienation. Design: A descriptive, correlational design was used. Setting: The study was conducted at El-Helal Insurance Hospital, Shebin EL-Kom Teaching Hospital, and University Hospital, in Menoufia governorate. Subjects: included a stratified random sample of nursing staff (n=717). Four instruments were used, Perceived Over-Qualification, creative self-efficacy, workaholism, and work alienation questionnaires Results: More than half of the study subjects had moderate levels of perceived over-qualification and creative self-efficacy. However, the highest percentages of study subjects had lower levels of both workaholism and work alienation. Conclusion: The overall score of perceived over-qualification had significant positive correlations with workaholism and a highly significant positive correlation with the overall score of work alienation. There were non-significant positive correlations between perceived over-qualification and the overall score of creative self-efficacy. Recommendations: Properly guiding and managing perceived overqualified nurses by hospital managers are important to make sure that they have the necessary resources to focus their extra effort and to employ their professional backgrounds and time on meaningful activities