Background: Femoral sheath removal post- cardiac catheterization may cause adverse events such as vasovagal reactions, local pain, bleeding and hematoma. Physical counter pressure maneuvers are safe, effective to reduce these risks. Aim: This study evaluated the effect of Physical counter pressure maneuvers during femoral sheath removal on adverse events for post- cardiac catheterization Patients. Design & Setting: A Quasi-experimental study was conducted in the Cardiac Care Units at both Tanta University Teaching Hospital and Tanta New Surgical Hospital Affiliated to the Ministry of Higher Education and Scientific Research. Subjects: A purposive sample of 100 patients post cardiac catheterization was divided into two groups, (50) patients in each group. Control group received standard routine care, whereas study group received physical counter pressure maneuvers with routine care. Tools: Data were collected using, Tool I, Cardiac Catheterization Patient‘s Assessment Tool and Tool II, Femoral Sheath Removal Adverse Events Assessment Sheet Results: The findings showed that none of patients in the study group experienced blurred vision, diaphoresis, or dizziness in contrast to (30%, 36% and 20%) in the control group respectively within 30 min after sheath removal where P=0.000*. Also A highly significant difference was observed between two groups in relation to pain severity, bleeding and hematoma within 30 min after sheath hematoma where P=0.000*.Conclusions &Recommendations: Physical counter pressure maneuvers (PCMs) effectively reduce adverse events associated with femoral sheath removal and should be integrated into routine care. Replication of the study on a large probability sampling