Background: Asthma is directly threatened by climate change. Exacerbations of asthma pose a serious health risk and are frequently made worse by climate change-related variables like increased exposure to allergens, air pollution, and extreme weather events. Aim: The study aimed to evaluate the effect of nursing interventions in reducing climate-related exacerbations among patients with asthma. Design: A quasi-experimental research design was used. Setting: The study was conducted at the respiratory outpatient clinic at Kasr El Aini University Hospital, affiliated with Cairo University, Cairo, Egypt. Subjects: A convenient sample of 120 adult male and female patients with asthma. Tools: Five tools were used to gather data. Tool I: Structured Interview Questionnaire for Patients with Asthma. This tool consists of three parts: Part 1, Patient‘s Socio-Demographic Characteristics; Part 2, Asthma Severity Assessment. Tool II, Knowledge about Climate-Related Asthma Triggers. Tool III: Perception about Climate-Related Asthma triggers. Tool IV: Asthma Control Test, and Tool V: Environmental exposure assessment. Results: There was a high improvement in patient knowledge in the pre-, post-, and follow-up after implementation of the nursing intervention program. The severity of asthma symptoms decreased by 25.0%, 5.0%, to 3.3. Asthma exacerbation decreased by 50%, from 16.7% to 8.3%. and emergency hospital visits is significantly decreasing by 50%, 5%, to 3.3%, respectively pre, post, and follow up. Conclusion: According to the study's findings, patients with asthma who received the nursing intervention program had a positive effect in reducing climate-related exacerbations and improved overall disease management. Recommendation: Healthcare providers in the respiratory department must hold educational workshops regarding how the climate can exacerbate asthma