411978

Fatigue in survivors of Childhood Acute Lymphoblastic Leukemia

Article

Last updated: 04 May 2025

Subjects

-

Tags

Pediatrics

Abstract

Background: The impact of therapy on psychosocial well-being is becoming more and more important as the survival rate for childhood Acute Lymphoblastic Leukemia (ALL) increases. There is a need for extensive research on fatigue throughout therapy. However, little information about this subject is known after treatment of ALL. The present work aims to assess fatigue experienced by adolescents and children after successful management for childhood ALL and its effect on the Quality of Life (QoL).

Methods: This cross-sectional comparative study included 30 children survivors of ALL and their parents. Another 30 healthy sex and age-matched children were recruited to serve as a control group. All survivors were conducted to complete history taking, full clinical examination, fatigue and QoL questionnaires.

Results: There was a remarkable variation between self-reported and parent-proxy fatigue scales including general, cognitive, and total fatigue scores among the survivors group (All parent-proxy domains were remarkably higher than self-reported) (P<0.001). There was a substantial adverse relationship between survivor-reported QoL and survivor-reported total fatigue score (p<0.001). There was a remarkable adverse association between parent proxy QoL of survivors and parent proxy fatigue (p<0.001).

Conclusion: This study suggests that adolescents and children survivors of ALL experience higher levels of fatigue compared to their healthy counterparts.

DOI

10.21608/zumj.2025.356751.3823

Keywords

Fatigue, Survivors, QOL, childhood, Acute lymphoblastic leukemia

Authors

First Name

Elhamy

Last Name

Abd El-khalek

MiddleName

Rifky

Affiliation

Professor of pediatric Faculty of Medicine - Zagazig University, Egypt

Email

elhamyrifky@yahoo.com

City

cairo

Orcid

-

First Name

Laila

Last Name

Sherief

MiddleName

M

Affiliation

Professor of pediatrics, Faculty of medicine - Zagazig university

Email

lamesh25@yahoo.com

City

-

Orcid

-

First Name

Eman

Last Name

El Safy

MiddleName

Roshdy

Affiliation

Professor of Psychiatry , Faculty of medicine - Zagazig university

Email

e.roshdy_safy@hotmail.com

City

-

Orcid

-

First Name

Marwa

Last Name

Azab

MiddleName

Mohamed Elsayed

Affiliation

MBBCH, Faculty of Medicine, Zagazig University

Email

m.azab2025@gmail.com

City

-

Orcid

-

Volume

31

Article Issue

5

Related Issue

55318

Issue Date

2025-05-01

Receive Date

2025-02-01

Publish Date

2025-05-01

Page Start

1,978

Page End

1,985

Print ISSN

1110-1431

Online ISSN

2357-0717

Link

https://zumj.journals.ekb.eg/article_411978.html

Detail API

http://journals.ekb.eg?_action=service&article_code=411978

Order

22

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

Fatigue in survivors of Childhood Acute Lymphoblastic Leukemia

Details

Type

Article

Created At

04 May 2025