Garlic (Allium sativum) is an edible tuber belonging to the family Liliaceae. Garlic has been studied for its medicinal and therapeutic effects in the treatment of various human diseases for a long time. Hypercholesterolemia is a known risk factor for cardiovascular diseases atherosclerosis, ischemic stroke, thrombosis and affects a high proportion of the population and affects a high proportion of the population. The present study is intended to study to compare the effect of different Types of garlic with and without peel on rats with high cholesterol levels, their role on oxidative Stress as an antioxidant, and Free Radicals. Forty-eight male rats were divided into two main groups as follows: The first basal group: (number = 6): It was fed the basal diet (as a negative control group). The second primary group: (number = 42): after the Induction of Hypercholesterolemia Then, rats were reclassified into (seven subgroups), each group consisting of (6 rats). Subgroup (1): They were fed the high cholesterol diet only (as a positive control group)., Subgroup(2, 3) were fed the high cholesterol diet and fortified with (5% - 10% garlic cloves powder / kg of diet), Subgroup(4, 5) were fed the high cholesterol diet and fortified with               (5% - 10% peels garlic powder / kg of diet) and Subgroup(6, 7) were fed the high cholesterol diet and fortified with (5% - 10%  garlic whole powder / kg of diet).Results showed that rats fed Types of garlic with and without peel had improved of body weight accompanied by a significant decrease in levels of glucose, insulin, liver functions (ALT and AST) Kidney Functions (U.A , Cr and UN ) Lipid Profile (TC , TG  , LDL and VLDL ) while were recorded a significant increase in a high-density lipoprotein-cholesterol (HDL)In addition, significantly reduced malondialdehyde (MDA) while the antioxidants enzymes (SOD , GPx and CAT ) was significantly (P<0.05) increased compared to Hypercholesterolemia rats and fed on basal diet alone. Finally, the existing study illustrated that Garlic (Allium sativum) improve  the Hypercholesterolemia.