Background: Spinal anesthesia provides a secure and dependable anesthetic approach for children undergoing lower abdominal surgeries. A quick onset of motor and sensory block, predictable rate of regression and minimal incidence of side effects are all characteristics of the ideal spinal anesthetic agent. The aim of this study was to compare spinal anesthesia using hyperbaric prilocaine 2% and hyperbaric bupivacaine 0.5% for children undergoing lower abdominal surgery. Methods: This study was conducted at Beni-Suef University Hospital on 50 patients. The patients were divided randomly into two equal groups; group A: received bupivacaine hydrochloride 0.5% and group B: received prilocaine Hydrochloride 2%. Demographic data, vital parameters, sensory‑motor block characteristics, and complications were noted. Results: Our study showed there was a highly significant difference regarding the block characteristics, where Prilocaine Group shows faster block onset time than Bupivacaine Group. Time to return to Bromage 0 was significantly shorter in Prilocaine Group than in Bupivacaine Group. Also; There was a significant longer recovery time, ambulation time and time of voiding of urine in the bupivacaine group than the prilocaine group. Conclusions: The present study shows that in children undergoing lower abdominal surgeries, Hyperbaric prilocaine provides faster onset time, shorter duration of action than bupivacaine. In addition, prilocaine showed less time for ambulation and voiding of urine with minimal side effects.