Background: Inherited genes and environmental factors play several roles in the etiology of vitiligo, a common skin depigmenting condition. For a long time, scientists have been unable to pin down the exact chemical mechanism that sets off the pathological process of vitiligo. Objectives: to identify miRNA337's function as a novel vitiligo marker. Methods: In the dermatology clinic at Beni-Suef University Hospital in Egypt conducted a case control study on 52 people, splitting them evenly between 26 people with vitiligo and 26 people without the condition. Cases with vitiligo went through personal history, physical examination, vitiligo severity index (VASI) score and blood samples in both groups. Quantitative real-time polymerase chain reaction analysis (PCR) was used to compare miRNA337 concentrations between the two groups. Results: MiRNA 337 was downregulated in the blood by a factor of two in patients compared to controls. MiRNA 337 levels in females' blood were somewhat greater than those in men', but this difference did not reach statistical significance. There was no association between VASI score, familial history, or precipitating circumstances and miRNA 337 levels in the blood. Conclusion: There was an inverse relationship between miRNA 337 levels and VASI score, suggesting that miRNA 337 was downregulated in vitiligo.