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425230

Intercellular Adhesion molecule-1 and Neutrophil Extracellular Traps in children on maintenance hemodialysis: Evidence of a chronic inflammatory state

Article

Last updated: 04 May 2025

OverviewSimilar Items

Subjects

-

Tags

Immunology
Pediatrics

Abstract

Background: Intercellular adhesion molecule-1 (ICAM-1) plays a key role in guiding leukocytes to sites of inflammation. Neutrophil extracellular traps (NETs) have been linked to vascular inflammation and blockages in patients with chronic kidney disease (CKD). The objective of this study was to measure serum levels of ICAM-1 and NETs both before and after a single session of high flux hemodialysis (HFHD) in children on maintenance hemodialysis. Methods: A total of 26 children who had been on HFHD for at least three months were enrolled, along with an equal number of healthy children matched for age and sex as controls. Patients with active inflammation, infections, or other relevant comorbid conditions were excluded from the study. Blood samples were collected from the patients both before and after their mid-week dialysis session to analyze complete blood counts (CBC), C-reactive protein (CRP), ICAM-1, and NETs levels. The same investigations were done for controls. Results: After the dialysis session, ICAM-1 and NETs levels showed a significant decrease compared to pre-dialysis measurements (p=0.000, p<0.0001 respectively). Despite this reduction, post-dialysis ICAM-1 and NETs levels remained higher than those observed in healthy controls (p=0.003, p=0.033, respectively). Conclusion: The findings support that end-stage kidney disease (ESKD) is characterized by ongoing inflammation. Unlike traditional views that suggest dialysis may add to the inflammatory process, our results indicate that effective hemodialysis can reduce inflammatory markers. Better dialysis membranes and novel modalities of dialysis should be tested to ensure they can exert a positive role in ameliorating this inflammatory status.

DOI

10.21608/ejpa.2025.376894.1089

Keywords

Chronic Kidney Disease (CKD), End Stage Kidney Disease (ESKD), High-flux hemodialysis (HFHD), kidney replacement therapy (KRT), immune reponse

Authors

First Name

Ragia

Last Name

Said

MiddleName

Marei

Affiliation

Division of Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine, Ain Shams University

Email

ragia_marei@med.asu.edu.eg

City

Cairo

Orcid

0000-0002-0067-5222

First Name

Mohammed

Last Name

Kasem

MiddleName

Faheem

Affiliation

Division of Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine, Ain Shams University

Email

mohsalfaheem@gmail.com

City

Cairo

Orcid

-

First Name

Noha

Last Name

Mohamed

MiddleName

Refaat

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Ain Shams University

Email

noha_refaat@med.asu.edu.eg

City

Cairo

Orcid

-

First Name

Noha

Last Name

Hashem

MiddleName

Usama

Affiliation

Division of Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine, Ain Shams University

Email

usnoha@gmail.com

City

Cairo

Orcid

-

Volume

23

Article Issue

1

Related Issue

55057

Issue Date

2025-04-01

Receive Date

2025-04-19

Publish Date

2025-04-01

Page Start

29

Page End

36

Print ISSN

1687-1642

Online ISSN

2314-8934

Article File

EJPA_Volume 23_Issue 1_Pages 29-36.pdf

PDF . 461.1kB

Link

https://ejpai.journals.ekb.eg/article_425230.html

Detail API

http://journals.ekb.eg?_action=service&article_code=425230

Order

425,230

Type

Original Article

Type Code

643

Publication Type

Journal

Publication Title

The Egyptian Journal of Pediatric Allergy and Immunology

Publication Link

https://ejpai.journals.ekb.eg/

MainTitle

Intercellular Adhesion molecule-1 and Neutrophil Extracellular Traps in children on maintenance hemodialysis: Evidence of a chronic inflammatory state

Details

Type

Article

Created At

04 May 2025