Background: Hyperbaric oxygen therapy has become increasingly popular among children due to its efficacy in the treatment of carbon monoxide poisoning and gas gangrene. The present study was aimed to evaluate the effect of educational intervention about Valsalva maneuver versus hot compresses on ear pain for children undergoing hyperbaric oxygen therapy. Design: A quasi-experimental research design was used. Setting: Hyperbaric Oxygen Therapy Unit of Tanta International Educational Hospital. Sample: A purposive sampling of thirty children aged 6-18 years who were undergoing hyperbaric oxygen therapy and were gathered from the aforementioned areas. Those children were divided into two equal groups; each group consisted of fifteen children. The study group 1of children received valsalva maneuver while the study group 2 was received hot compresses. Three tools were used Tool I: Children's knowledge interview schedule consisted of three parts. Tool II: Observational Checklist. Tool III: Children's Wong-Baker Face Pain Rating Scale. Results: Regarding mean total scores of children's ear pain severity, at the beginning, during and after receiving hyperbaric oxygen therapy there were statistically significant differences among Valsalva maneuver group children and among hot compresses group children. Conclusion: Both Valsalva maneuver and hot compresses (D-Mid hot packs) were beneficial in alleviating the severity of children's ear pain and equalizing ear pressure at the beginning, during, and after hyperbaric oxygen therapy session. Recommendations: Newly admitted children undergoing hyperbaric oxygen therapy should have an educational intervention about knowledge and practices for using Valsalva maneuver and hot compresses to reduce ear pain and equalize ear pressure.