During this study, physical and chemical parameters were measured along the Tigris River in four locations extending between Hammam Al-Alil and Al-Salamiyah for the period of August 2024 to January 2025. This study aimed to evaluate the Tigris River water and its suitability for drinking and human use at sites 1, 2, 3, and 4. Physical, chemical, and biological parameters such as pH, air and water temperature, electrical conductivity (EC), total dissolved solids (TDS), total alkalinity, active phosphate (PO₄), nitrite (NO2), chloride (Cl), active silica (SiO₂), and total platelet count (TPC) were studied. Some of these parameters were tested in the field and others in the laboratory. Most of the tested parameters were found to be compatible with international and Iraqi drinking water specifications,  except for the total platelet count (TPC) (especially at station 4), which was significantly high, reaching 48.16 * 10² cells/ml. Values of pH and water temperature ​​ranged between 6.23- 7.31 and  7-24°C, respectively, while the electrical conductivity (EC) was 341.16 micro siemens/cm. The average value of total dissolved solids (TDS) was determined at 185.20mg/ L, and dissolved oxygen (DO) at 6.6mg/ L, whereas ranges of the silica value were detected between 1.00-2.1µg/ L; in addition, the effective phosphate rate was 0.11µg /L, and the nitrite value ​​was 0.19µg/ L.