Chronic kidney disease (CKD) has been recognized as a leading public health problem worldwide. The neutrophil - to- lymphocyte ratio (NLR) had been shown as a marker of systemic inflammation. However Studies are inconsistent about NLR and clinical outcome in patients with CKD, so we aimed to clarify the relationship between Neutrophil - lymphocyte ratio and the disease progression in chronic kidney diseases (CKD). This is a prospective observational study conducted on 60 patients with CKD stage 2-4 followed up in the period between March (2021) to November (2021). Patients were divided according to the median level of NLR into high and low NLR groups. Our study showed adverse renal outcome in the high NLR group with 13 patients dialyzed versus 2 in the low NLR group. 19 patients showed stationary coarse and 4 was progressed in the low NLR group versus 5 patients showed stationary and 19 was progressed in the high NLR group.  We concluded that NLR was a risk factor for progression and poor renal outcome in chronic kidney disease patients with stage 2-4, so it might be a useful predictor marker for renal outcome in CKD patients.