Background: Placing a central venous catheter (cvc) is a crucial invasive surgery that children of all ages undergo in the operating theater and the intensive care unit. the purpose of this study was to compare two methods for subclavian venous catheterization in pediatric patients: ultrasound-guided supraclavicular (sc) and infraclavicular (ic). the goal of this comparison is to help clinicians practice cvc insertion with more speed, accuracy, and less problems. Methods: This prospective, randomized, single-blinded clinical trial administered to forty children, comprising both sexes, between the ages of four and twelve, American society of anesthesiologists I, II, III physical status, needing central venous line insertion, intra-operative hemodynamic monitoring, volume, inotrope resuscitation, difficult peripheral Intravenous access and intravenous nutrition and medications. There were two groups of patients: SC and IC. Results: The groups were significantly different according to puncture time, total access time, guidewire misplacement and catheter insertion length. Catheter insertion duration, quality of needle visualization, number of attempts, and first attempt success rate were not significantly different across the groups that were evaluated. There was no significant difference between studied groups according to pneumothorax and hematoma. Conclusions: SCV catheterization in pediatric patients in comparison to the IC approach, resulted in a reduced puncture time and a reduction in the occurrence of guidewire misplacement.