Background: Nurses are the key to achieving effective health care and providing high-quality care to patients in the hospital. On the other hand, they suffer from a lot of workload and insufficient resources, resulting in organizational cynicism. Aim of the study: was to determine the relationship between perceived organizational support and organizational cynicism among staff nurses. Design: a descriptive correlational design was used for conducting this study. Setting: The study was carried out at cardio vascular surgery hospital which affiliated to aim shams university hospital. Subjects: A staff nurses working in the aforementioned study were recruited in the study their total number is (120). Data collection tools: Were collected using perceived organizational support questionnaire, and organizational cynicism scale. Results: Showed that there was more than two-fifths of the studied staff nurses have a high perception level regarding supervisor support. While, near to one-quarter of them have low perception level regarding job conditions. There was less than three-quarters of the studied staff nurse have low level of organizational cynicism regarding affective cynicism. Conclusion: There was a highly significant negative correlation between total perceived organizational support levels, and organizational cynicism levels. Recommendations: Employees will have opportunity to share their opinions without fear. Provide the head nurses attention to employee complaints, understand what absenteeism causes, and don't ignores any extra effort from nurses .Additionally further research is recommended as evaluate perceived organization support and its relation to work engagement