Non-steroidal anti-inflammatory drugs (NSAIDs) are the most common cause of peptic ulcers (approximately 25%). Because synthetic drugs frequently have side effects, using natural plant extracts, is now thought to be an alternative method of treating the condition. Since the use of herbal products has been increasing, the study's objectives were to determine the chemical composition and total phenolic compounds of Indian gooseberry fruit and Neem leaves as well as to study the possible protective effects of aqueous extracts from Indian gooseberry and Neem leaves and their mixture on oxidative stress and ulcer healing in rats. After adjusting for a week, thirty female Wister rats weighing 150 ±10 g were split up into two major groups. As a negative control group, Group (1) was the first to be fed the basal diet (-ve). The second major group divided into 4 groups as follow: Group (2), the Positive Control Group (+ve), was given distilled water orally every day. And 500 mg/kg BW/day of aqueous Indian gooseberry extract was administered orally as a pretreatment to Group (3). Aqueous extract of Neem leaves (350 mg/kg BW/day) was administered orally as a pretreatment to Group (4). 250 mg of Indian gooseberry +250 mg of Neem / kg BW/day were administered orally as a pretreatment to Group (5).  All rats, with the exception of those in the negative control group, received a single oral dosage of 500 mg acetyl salicylic acid/ kg BW, after 21 days of pretreatment. Rat groups' stomachs and livers were collected for further examination at the completion of the experiment (21 days). Results showed that, ingestion of Aspirin at 500 mg/ kg BW resulted in significant increases of gastric juice volume and in the pH of gastric juice, with significant increment of gastric mucosal injury area when compared with values of the negative control group, on the other hand ingestion of aqueous extract of Indian gooseberry, Neem and their mixture enhanced the gastric protection by increasing the ulcer inhibition percentage, ingestion of Aspirin resulted in a notable and significant increase of gastric and liver MDA, and both reduced glutathione (GSH) and (Catalase) showed significantly lower values as compared with negative control group. In groups of rats treated with gooseberry, Neem and their mixture there were a significant reduction in MDA and significant increments in GSH and CAT of stomach and liver tissues. From these results it could be concluded that both Indian gooseberry and Neem were effective in preventing gastric ulcer and reducing oxidative stress.