Background: The neutrophil-to-lymphocyte ratio (NLR) is the index that indicates systemic inflammatory changes after transplantation. Aim: The present study aimed to determine the role of NLR and PLT count in early allograft dysfunction (EAD) development after liver transplantation (LT). Patients and Methods: One hundred twenty patients with living donor liver transplantation in Gastrointestinal Surgery Center Mansoura University were determined throughout the present study. Patients were divided into two main groups: Eighty-two non-early allograft dysfunction group (NEAD) and thirty-eight early allograft dysfunction group (EAD). Blood levels of neutrophil, lymphocyte and platelets were estimated at preoperative day and postoperative days from day one to day seven using complete blood count (CBC) data. The NLR was calculated as the ratio of neutrophil count to lymphocyte count. Results: The NLR ratio showed significant difference between the two groups (p<0.05) on post- operative days from day 2 to day 7. The area under curves (AUC) ranged from 0.630 to 0.676 with sensitivity from 68% - 81%, specificity from 52% - 59%. However, PLT in EAD group showed significant difference (p<0.05) on preoperative day and highly significance on postoperative days from day1 to day 7 compared to NEAD group and exhibited area under curves (AUC) ranged from 0.618 to 0.682 with sensitivity from 65% - 81%, specificity from 52% - 59%. Conclusion: Determination of NLR ratio and PLT count were associated with EAD development from post-operative day 1 to post-operative7 after liver transplantation and maybe as useful biomarkers for EAD prediction.