The present study aimed to determine the role of some biochemical markers to predict EAD development after living donor liver transplantation (LDLT). Patients and Methods: One hundred twenty patients under went living donor liver transplantation were subjected. Patients were divided into two groups: Eighty-two non-early allograft dysfunction group (NEAD) and thirty-eight early allograft dysfunction group (EAD). Blood levels of different biological markers were estimated at preoperative day and postoperative from day one to day seven using bio and immunochemical assays. Results: Some of biochemical marker levels on preoperative day and on different postoperative days from day one to day seven were significantly different in EAD than NEAD group (p values ranged from < 0.05 to < 0.0001). Conclusion: Some blood biomarkers on preoperative and postoperative days from day one to day seven were correlated with EAD development and the four current models had a significant prediction potential for EAD in LDLT.