This purpose of this experiment was to evaluate the effect of compost (0, 5, 7.5 and 10 t/fed.) and some natural extracts (control, active yeast at 5 and 10 g/l, seaweed extract at 1.5 and 3 ml/l and moringa leaf extract at 10 and 20%) on growth, yield and some chemical constituents of white mustard plants during 2022/2023 and 2023/2024 at the Farm of Medicinal plants, Faculty Agriculture, Minia University, Egypt. Data showed that all vegetative growth parameters (plant height, number of branches, and fresh weight), yield traits (number of pods per plant and seed yield per plant), fixed oil production (percent and yield per plant) and some chemical constituents (NPK% and photosynthetic contents) were significantly increased with fertilizing plants with compost relative to control during both seasons with the highest values were obtained with 10 ton compost per feddan. All six used treatments of natural extracts considerably increased all above-mentioned parameters comparing to the control through both seasons. Seaweed extract at 3 ml/l was superior in this regard. The best interaction treatment was to fertilizing white mustard plants with compost at 10 t/fed. and seaweed extract (3 ml/l), followed by active yeast (10 g/l).