Aim: This study aimed to assess the awareness of patient regarding multiple sclerosis at al-Monira outpatient clinics. Research design: A descriptive study design was used to conduct the study. Setting: Brain and Nerve Clinic at Al-Monira Outpatient Clinics. Sample: Purposive sample used to choose 110 patients. Tool of data collection: One tool included five parts, Results: 60.2 % of the studied patient had poor knowledge. While, 55.1 % of them had unsatisfactory total reported practices regarding multiple sclerosis and 70.2 % of the studied patient had negative total attitude. There was highly statistically significant relation between studied patient's total knowledge, total reported practices and total attitude and all items of demographic characteristics Conclusion: More than quarter of the studied patients had average total knowledge, and less than half of them had satisfactory total reported practices. While, less one third had positive total attitude toward multiple sclerosis. There a relation between patients' knowledge, reported practices and attitude towards multi sclerosis. There is highly statistically significant relation between patients' demographic characteristics and their knowledge, reported practices and attitude towards multiple sclerosis. Recommendations: Provide health education program for patients about multiple sclerosis to improve their condition.