Background: Primary dysmenorrhea (PD) is the most com-mon gynecological problem in women during the menstruation, its associated complications have a negative effect on well- be-ing and quality of life of women. Aim of Study: This study was conducted to ascertain wheth-er combining low-level laser therapy (LLLT) with anti-inflam-matory diet (AID) have an effect on primary dysmenorrhea (PD). Patients and Methods: The study involved 35 females di-agnosed with PD, aged 20-35 years, with body mass indices between 18-29.9kg/m2. Participants were randomly assigned to two groups: Group A (n=17) received LLLT alone, while Group B (n=18) received both LLLT and AID. Both interventions were administered over three consecutive menstrual cycles. The out-come measures, including serum levels of C-reactive protein (CRP), scores of menstrual distress questionnaire (MDQ), and visual analogue scale (VAS), were evaluated at baseline and after treatment. Results: A statistically significant improvement was ob-served in CRP, MDQ, VAS in both groups after treatment com-pared to before treatment (p<0.05), by comparing both groups post-treatment there was no significant difference between both groups (p>0.05) but the percentage of improvement in CRP and MDQ was high in group B than in group A (15.46% versus 17.89%), (20.25% versus 26.32%) respectively. Conclusion: A program of combined LLLT and AID has a better effect on management of PD rather than LLLT alone.