Zoonotic diseases are prevalent all over the world and pose a significant threat to humans and animals. The tight connection between people and animals promotes the spread of zoonotic diseases. One of the main worldwide hotspots for zoonotic transmission to humans is Bangladesh. Bangladeshi people (farmers, laborers, butchers, and live animal market workers) are at high risk of it. Anthrax, brucellosis, Nipah, rabies, avian influenza, and zoonotic tuberculosis are among the six diseases that the Bangladeshi government has designated as priority zoonotic diseases. Pabna and Sirajgonj districts in Bangladesh are known as the "anthrax belt" due to high animal anthrax cases. Brucellosis, a neglected zoonotic disease, is a class B bioterrorist agent, affecting individuals in high-risk occupational groups in Bangladesh. A study revealed that zoonotic TB has a prevalence rate of 6.67% in humans in Bangladesh. The first Nipah virus disease was first identified in 2001. Since then, 335 individuals have been infected with the NiV virus, with 237 dying; the fatality rate is 70% in Bangladesh. Bangladesh has the 3rd highest number of human rabies deaths among rabies-endemic nations, with over 200,000 animal bite cases. To overcome this, it's necessary for a one-health approach to combat this public health hazard.