Background: Intussusception is a common cause of intestinal obstruction during infancy and childhood. Treatment in early cases is non-surgical including hydrostatic or pneumatic reduction, adjuvant corticosteroids can be added to increase the non-surgical management success rate . Dexamethasone is a long rapidly acting corticosteroid, this study aim to evaluate its efficacy in high and low doses to minimize the need for surgical treatment. Methods: A prospective controlled clinical trial conducted on patients divided into three groups, group (A) received low dose of dexamethasone, group (B)received high dose dexamethasone and group (C) received normal saline. Patients presenting with early symptoms were selected. Patients were subjected to 3 pneumatic reduction trials if the first and second trials were unsuccessful. Dexamethasone was given once before first trial only. Results: The study involved 101 patients from January 2023 to December 2023, 34 patients in group (A), 34 patients in group (B) and 33 patients in group (C). Across all trials, a total of 70 patients (69.3%) achieved success; 82.4% of group A, 88.2% of group B, achieved success and 36.4% of group C. 64 out of 70 patients (91.4%) were successful from the first trial. We found a statistically significant increase in success rate among groups taking dexamethasone either in low or high doses and the group taking saline with no significant difference comparing low with high dose dexamethasone. Conclusion: The dexamethasone usage before intussusception pneumatic reduction is effective in avoiding surgical management, more studies should be conducted to be used before every trial.