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409788

Assessment expression of Serum Amyloid A and LncRNAAF085935 in patients with Hepatocellular Carcinoma, Hepatitis B and Hepatitis C Virus

Article

Last updated: 27 Apr 2025

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-

Tags

Gastroenterology

Abstract

Long non coding RNAs (Lnc RNAs) and serum Amyloid A (SAA) have been suggested to have a role in hepatocarcinogenesis. In this work, to investigated the role of lnc RNA AF085935 and SAA as diagnostic biomarkers in sera of HBV, HCV, HCC patients. Subjects and Methods: HBV genotyping was assessed by. Lnc RNAAF085935 quantitative gene expression in whole blood by real time PCR and the SAA expression was measured using ELISA. 149 adult Egyptian subjects were divided into 35 HCC patients on top of HCV and 24 HCC patients on top of HBV, 35patients with HBV, 35 patients with HCV and 20 controls. Results: HBV genotype D was found in all of the samples. In HCC patients, HCV patients, and HBV patients; the levels of LncRNA-AF085935 and SAA were significantly upregulated than in healthy controls. (p value = <0.001). In addition, higher expressions of both LncRNA-AF085935 and SAA (p value = <0.001) were observed in HCC/HBV and HCC/HCV patients than in HCV or HBV patients. Conclusion: Lnc RNA-AF085935 and SAA were observed with an aberrant level in sera of HCC, HCV and HBV patients. Lnc RNA-AF085935 and/or SAA can be considered to be used as potential biomarkers in HCC.

DOI

10.21608/arcmed.2025.342192.1084

Keywords

hepatitis B, Hepatitis C virus, Hepatocellular carcinoma, LncRNAAF085935, Serum Amyloid

Authors

First Name

Haitham

Last Name

El- Hadidy

MiddleName

Abbas

Affiliation

General Manager of School of Medicine BUC,Lecturer of Hospital Administration, MMA

Email

haithamelhadidy63@gmail.com

City

-

Orcid

-

First Name

Dina

Last Name

sabry

MiddleName

-

Affiliation

Medical Biochemistry and Molecular Biology department, Faculty of medicine, Cairo University.

Email

dinasabry@kasralainy.edu.eg

City

cairo Egypt

Orcid

-

First Name

Moataz

Last Name

Maher

MiddleName

-

Affiliation

Medical Biochemistry and Molecular Biology department, Faculty of medicine, Cairo University.

Email

zoma45@yahoo.com

City

Cairo Egypt

Orcid

-

First Name

Abeer

Last Name

Abd El kader

MiddleName

Eid

Affiliation

Medical Biochemistry and Molecular Biology department, Faculty of medicine, Cairo University.

Email

victoria_ggirl2010@yahoo.com

City

cairo Egypt

Orcid

-

First Name

Hend

Last Name

Shousha

MiddleName

Ibrahim

Affiliation

Endemic medicine and Hepatogastroenterology, Faculty of medicine, Cairo University

Email

domoya2019@gmail.com

City

cairo Egypt

Orcid

-

First Name

Haneya

Last Name

Anani

MiddleName

-

Affiliation

Medical microbiology and Immunology department, Faculty of Medicine for Girl, AL- Azhar University

Email

haneya.amr2008@yahoo.com

City

Cairo Egypt

Orcid

-

First Name

Nihal

Last Name

Diaa

MiddleName

-

Affiliation

Clinical and Chemical Pathology Department, Consultant Clinical Pathology, Cairo University Hospitals, Cairo, Egypt

Email

nehaldiaa@hotmail.com

City

Cairo Egypt

Orcid

-

Volume

3

Article Issue

1

Related Issue

55095

Issue Date

2025-04-01

Receive Date

2025-01-15

Publish Date

2025-12-01

Page Start

1

Page End

10

Online ISSN

2812-5509

Article File

ARCMED_Volume 3_Issue 1_Pages 1-10.pdf

PDF . 496.8kB

Link

https://arcmed.journals.ekb.eg/article_409788.html

Detail API

http://journals.ekb.eg?_action=service&article_code=409788

Order

409,788

Type

Review Articles

Type Code

2,395

Publication Type

Journal

Publication Title

ARCADEs of MEDICINE

Publication Link

https://arcmed.journals.ekb.eg/

MainTitle

Assessment expression of Serum Amyloid A and LncRNAAF085935 in patients with Hepatocellular Carcinoma, Hepatitis B and Hepatitis C Virus

Details

Type

Article

Created At

27 Apr 2025