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The Potential Protective Effects of Brown Algae (Sargassum subrepandum) Powder on Benzo[A]Pyrene-Induced Hepatic and Renal Dysfunction in Rats

Article

Last updated: 27 Apr 2025

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Subjects

-

Tags

Food Science and technology

Abstract

Benzo[a]pyrene (B[a]P) is a primary representative of polycyclic aromatic hydrocarbons (PAHs) that are produced during various food preparation and processing methods, such as baking, frying, grilling, and smoking. Exposure to B[a]P has been linked to liver toxicity and carcinogenic effects across all vertebrate species. This study aims to explore the potential protective effects of brown algae (Sargassum subrepandum) powder on benzo[a]pyrene-induced hepatic and renal dysfunction in rats. Thirty male albino rats were classified into two main groups, the first group (G1, 6 rats, as a negative control group) was fed the basal diet (BD) and the second main group (24 rats), challenged with B[a]P, was assigned to four groups of 6 rats per each as follow: group 2 (G2) acted as a model control of hepatotoxic rats, while groups (3-5) received Sargassum subrepandum powder (SSP) at concentrations of 1.5, 3.0 and 6 g/100g diet for 28 days each, respectively. B[a]P exposure significantly (p≤0.05) increased liver enzymes activities [AST (72.27%), ALT (95.94%), ALP (243.01%) and GGT (670.08%)], renal function indicators [serum urea, (231.88%), uric acid (170.05%) and creatinine (79.36%)], and  MDA (2984.37%) accompanied by severe histopathological changes in liver and kidney tissues comparing to the normal control group. Also, a significant (p≤0.05) deficiency in antioxidant enzymes [SOD (-78.14%), CAT (-97.35%) and GPX
(-89.82%)], GSH (-86.98%), and immunoprotenis [albumen (-31.15%) and globulin (-30.62%)] were recorded. Treatment with SSP for 24 days exhibited a significant (p≤0.05) improvement in all of these parameters and the histoarchitecture of the liver and kidneys by different rats. The improvement in all assessed parameters demonstrated a dose-dependent response to the SSP intervention. In conclusion, the present results from this study indicate that treatment with SSP at the evaluated concentrations effectively mitigated the biochemical and histological injuries to the liver and kidneys induced by B[a]P, highlighting the potential of this intervention.

DOI

10.21608/asejaiqjsae.2025.422182

Keywords

liver enzymes, Renal functions, Bilirubin, Antioxidant enzymes, plasma proteins, histopathology

Authors

First Name

Yousif

Last Name

Abd Elasis Elhassaneen

MiddleName

-

Affiliation

Department of Nutrition and Food Science, Faculty of Home Economics, Minoufiya University, Shebin El-Kom, Egypt

Email

yousif12@hotmail.com

City

Shebin El-Kom,

Orcid

0000-0003-1391-3653

First Name

Asmaa

Last Name

E. Menusy

MiddleName

-

Affiliation

Department of Nutrition and Food Science, Faculty of Home Economics, Menoufia University, Shebin El-Kom, Egypt

Email

-

City

-

Orcid

-

First Name

Amal

Last Name

Zaki

MiddleName

Nasef

Affiliation

Nutrition & Food Science, Faculty of Home Economics , Menoufia University, Shibin El-Kom, Egypt

Email

amal.nasif1@hec.menofia.edu.eg

City

-

Orcid

0000-0002-7054-8659

Volume

46

Article Issue

2

Related Issue

55036

Issue Date

2025-06-01

Receive Date

2025-03-05

Publish Date

2025-06-30

Page Start

187

Page End

209

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 46_Issue 2_Pages 187-209.pdf

PDF . 674.3kB

Link

https://asejaiqjsae.journals.ekb.eg/article_422182.html

Detail API

http://journals.ekb.eg?_action=service&article_code=422182

Order

1

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

The Potential Protective Effects of Brown Algae (Sargassum subrepandum) Powder on Benzo[A]Pyrene-Induced Hepatic and Renal Dysfunction in Rats

Details

Type

Article

Created At

27 Apr 2025