Purpose of the study: Evaluating the influence of combination of vitamin D3 with particulate bovine xenograft when placed in post-extraction sockets on the newly formed bone quality.
Primary outcome: Implant primary stability
Secondary outcomes: Radiographic bone density and immunohistochemical expression of osteopontin in newly formed regenerated bone
Subjects and methods: Patient with non-restorable maxillary anterior tooth or single root premolar that require extraction and dental implant. Test group: 13 extraction sites received particulate xenograft mixed with vitamin D3. Control group: 13 extraction sites received particulate xenograft alone. After 6 months implants were placed. Implant primary stability, radiographic bone density, immunohistochemical osteopontin expression in grafted sites were evaluated.
Results: A significantly higher mean value of both primary stability and bone density were recorded in test group.
Conclusion:
Taking in considerations the limitations of the current study, the addition of vitamin D to particulate xenogenic bone graft enhanced newly formed bone density, implant stability and is associated with increased expression of OPN level in grafted sites.