Background: Oral diseases affect billions worldwide and significantly impact overall well-being and quality of life. Medical practitioners are essential for integrating oral health into their practice, as early recognition and management of these often treatable conditions can lead to improved health outcomes. Objective: The primary objective of this study was to assess the dental knowledge, attitudes, and awareness of medical practitioners in Benghazi, Libya, and to identify gaps in their understanding of oral health and its connection to systemic health. The study also aimed to explore the role of medical practitioners in promoting oral health and their ability to recognize and manage dental emergencies and systemic conditions with oral manifestations. Results: The study revealed that a majority of general practitioners (80.6%) and exhibited varying levels of dental knowledge. While 76.9% understood the importance of daily brushing in preventing tooth decay, misconceptions regarding dental issues were prevalent, such as only 38% associating brushing with oral ulcers. Awareness of dental emergencies was mixed; for instance, only 42.8% correctly identified Ludwig's angina as a dental infection, highlighting gaps in knowledge about critical conditions. Conclusion: The study highlighted the need for improved dental education among medical professionals in Benghazi to enhance patient care and early detection of dental-related conditions. The findings underscore the importance of integrating dental knowledge into medical practice to ensure comprehensive healthcare delivery.