Amphora coffeaeformis (A. coffeaeformis) is a unicellular microalga existing in the majority of marine environments and can accommodate various levels of salinity. It could be harvested easily and has a very plentiful amount of macronutrients and micronutrients, essential amino acids, proteins, lipids, vitamins, minerals, and antioxidants. A.coffeaeformis has recently received a lot of interest from researchers as a promising source of nutraceuticals and for its potent biological capabilities, such as antioxidant, anti-inflammatory, therapeutic, and immunological attributes. Raising our knowledge of the metabolic composition of this alga is critical to recognising the future potential of its co-products. Consequently, the purpose of this review is to spotlight on A. coffeaeformis, its chemical composition, nutritional importance, and the bioactive components that are responsible for its beneficial properties, thus offering opportunities for using this alga as a feed additive or ameliorating agent against several poisons. Future studies should expand A. coffeaeformis screening attempts to cover its novel applications.