Aim of the study: is to evaluate the effect of tetracycline socked pack on acceleration of healing during marsupialization as a primary treatment for locally invasive lesions.
Participants and methods: A single blind randomized control clinical trial on a total of 14 healthy patients of either gender aged from 20-40 years who are seeking treatment of a painful intra-body mandibular swelling cystic lesions 3 x 4 cm in size with biopsy conformation that the lesion is a unicystic ameloblastoma. They were treated with either tetracycline socked pack during marsupialization or conventional marsupialization procedure. CBCT radiographic assessment evaluated volumetric changes of the lesion at 3 and 6 months postoperative.
Results: All cases showed positive healing indications. At 3 months no statistically significant difference between control and test groups was shown. However, at 6 months, a significant difference emerged; indicating that the test group achieved a significantly higher percentage of volume reduction compared to the control group at the 6-month mark. Both groups showed highly significant internal improvements over time (p<0.001), but the test group demonstrated a more pronounced reduction percentage
Conclusion: Marsupialization combined with tetracycline socked pack as a primary management for unicystic ameloblastoma has positive effect on lesion shrinkage and may aid in acceleration of healing.