Aim of the study: is to assess the influence of low-level laser therapy (LLLT) on post-operative pain and bone healing when used prior to and following enucleation of cystic lesions. Participants and methods: twenty healthy patients of either gender aged from 20-50 years who were seeking cyst enucleation of intra-bony maxillary cystic lesions approximately 2 x 3 cm in size equally and randomly allocated to either test group or control group. Group was treated Pre and post-operative low level laser treatment at the site of cyst enucleation of intra-body maxillary cystic lesions. Post- operative pain assessment was recorded on visual analog scale (VAS) every 24h for 7 days in addition to radiographic assessment via CBCT scan obtained immediately post-operative, 3 and 6 months postoperative. Results: Regarding postoperative pain at 24 hours, no significant difference between the two groups at p value of (0.190). Yet, at 48 hours a significant differences emerged with p value of (0.012) and at 7 days a p value of (0.010), with the test group showing lower pain scores. As for The bone density measurements a significant difference emerged at 3 months (p=0.008), with the test group showing a higher mean bone density. By 6 months, the difference became non-significant (p=0.186), though the test group maintained a higher mean value. Conclusion: Application of low level laser therapy prior to and after enucleation of intra-body cystic lesions is beneficial in postoperative pain relief and early bone healing.