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Correlation Between Adhesion Molecules (ICAM-1 & E-Selectin) and Diagnostic Antibodies (TTG & AGA) in Celiac Disease

Article

Last updated: 27 Apr 2025

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-

Tags

Clinical microbiology

Abstract

Background: Celiac disease (CD) is a chronic autoimmune disorder triggered by gluten ingestion in genetically susceptible individuals, characterized by intestinal inflammation, villous atrophy, and the production of specific autoantibodies, including anti-tissue transglutaminase (TTG) and anti-deamidated gliadin peptides (AGA). Endothelial adhesion molecules, such as intercellular adhesion molecule-1 (ICAM-1) and E-selectin, play a pivotal role in immune cell recruitment and inflammation. Objective: This study aimed to evaluate the correlation between the gene expression of ICAM-1 and E-selectin and serum levels of diagnostic antibodies (TTG-IgA, TTG-IgG, AGA-IgA, and AGA-IgG) in CD patients. Methodology: A case-control study was conducted involving 124 CD patients and 60 healthy controls. Gene expression of ICAM-1 and E-selectin was quantified using reverse transcription-polymerase chain reaction (RT-PCR), while serum antibody levels were measured via enzyme-linked immunosorbent assay (ELISA). Results: A significant positive correlation was observed between TTG-IgA and TTG-IgG levels (r = 0.85, P < 0.001), whereas AGA-IgA and AGA-IgG exhibited a weak correlation (r = 0.12, P=0.187). ICAM-1 and E-selectin expression was significantly downregulated in CD patients compared to controls (P < 0.001), with a strong positive correlation between the two molecules (r=0.86, P<0.001). ICAM-1 expression demonstrated a moderate positive correlation with antibody levels (P<0.05), suggesting its involvement in immune activation and inflammation in CD. In contrast, E-selectin expression did not significantly correlate with antibody levels, indicating a more complex or indirect role in CD pathogenesis. Conclusion: These findings highlight the potential of ICAM-1 as a biomarker for immune activation in CD and suggest that endothelial adhesion molecules may contribute to disease progression. Further research is warranted to elucidate their precise mechanisms in CD pathogenesis.

DOI

10.21608/ejmm.2025.371261.1532

Keywords

Celiac disease, Endothelial adhesion molecules, ICAM-1, E-selectin, Autoantibodies

Authors

First Name

Fatima

Last Name

Kareem

MiddleName

M.

Affiliation

Pathological Analyses Department, Faculty of Science, University of Kufa

Email

fatimam.ali@student.uokufa.edu.iq

City

najaf

Orcid

-

First Name

Hawraa

Last Name

Abdulammer

MiddleName

A.A.

Affiliation

Pathological Analyses Department, Faculty of Science, University of Kufa

Email

hawraabdulam88@gmail.com

City

najaf

Orcid

-

Volume

34

Article Issue

4

Related Issue

54773

Issue Date

2025-10-01

Receive Date

2025-03-25

Publish Date

2025-10-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_422784.html

Detail API

http://journals.ekb.eg?_action=service&article_code=422784

Order

422,784

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Correlation Between Adhesion Molecules (ICAM-1 & E-Selectin) and Diagnostic Antibodies (TTG & AGA) in Celiac Disease

Details

Type

Article

Created At

27 Apr 2025