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422782

Evaluation of serum miRNA21 and interleukin-15 in Celiac disease patients

Article

Last updated: 27 Apr 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Celiac disease (CD), also known as "celiac sprue," is a persistent inflammatory condition that involves the small intestine, with an incidence of 1% in the majority of the population. Objective: This study aimed to investigate the role of interleukin-15 (IL-15) and MicroRNA21(miRNA21) among patients with Celiac Disease and comparing it with healthy controls. Methodology: This study was conducted on a total of (150) individuals in different sex and age group cases (40 males + 110 females) including (75) patients with Celiac Disease and (75) healthy individuals. CD patients were recruited at the Medicine Unit at Al-Sadder Medical City and the Specialized Hospital for Gastroenterology and Hepatology in Al-Najaf province. All patients were diagnosed with CD by serological and histological tests. The age range of the study population was from (3-45) years. Blood was drawn from a vein, to investigate microRNA21 by one-step qRT-PCR and IL-15 by ELISA technique. Results: The findings revealed that the mean of miRNA21 and IL-15 were elevated in CD patients compared to healthy people. Celiac Disease patients had a significantly higher mean of IL-15 than the healthy Group, 327.4 vs. 163, respectively (P.value <0.001). miRNA-21 expression was significantly upregulated in CD patients (fold change=6.21), compared to a control group (fold change=1.04). (P=< 0.001) Conclusion: The miR-21/IL-15 interaction may contribute to Celiac disease pathogenesis. Moreover, miR-21/IL-15 could be utilized as a biomarker to diagnose psoriasis and to assess its severity.

DOI

10.21608/ejmm.2025.370473.1530

Keywords

IL-15, MicroRNA21, patients, Celiac disease

Authors

First Name

Angham

Last Name

Ali

MiddleName

J.M.

Affiliation

Al-Furat Al-Awsat Technical University, Kufa, Iraq

Email

angham.ali11@atu.edu.iq

City

najaf

Orcid

-

First Name

Ruaa

Last Name

Jaber

MiddleName

M.

Affiliation

Al-Furat Al-Awsat Technical University, Kufa, Iraq

Email

mohsenruaa6@gmail.com

City

-

Orcid

-

Volume

34

Article Issue

4

Related Issue

54773

Issue Date

2025-10-01

Receive Date

2025-03-22

Publish Date

2025-10-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_422782.html

Detail API

http://journals.ekb.eg?_action=service&article_code=422782

Order

422,782

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Evaluation of serum miRNA21 and interleukin-15 in Celiac disease patients

Details

Type

Article

Created At

27 Apr 2025