Introduction: COVID-19's clinical manifestations and severity range from no symptoms to severe or lethal. Coronavirus sequelae can include anosmia (loss of smell), fever, dry cough, fatigue, and dyspnea and ageusia. Numerous symptoms of the central and peripheral neurological systems, such as cerebrovascular disease, reduced consciousness, and vision impairment, have been recorded; however, it is difficult to determine if these are COVID-19 complications or drug side effects. The majority of SARS patients reportedly experienced common complaints like insomnia, poor attention, and memory loss, along with symptoms of anxiety and sadness, suggesting cognitive deficits following SARS infection [1]. Cognitive deficiencies were also linked to the clinical symptoms of depression and anxiety disorders in individuals [2]. Nevertheless, it is still unclear if cognitive damage is linked to SARS-CoV-2 infection.

Aim of the work: Assess how the new coronavirus affects cognitive abilities in Sohag Governorate patients with confirmed COVID-19.

Results: P300 amplitude revealed a highly significant difference (p<0.001), while P300 latency revealed a statistically significant difference (p<0.05) between patients and controls and COVID-19 patients and controls differed statistically significantly (P-value <0.05) in naming and visuospatial.

Conclusion: In COVID-19 patients, cognitive function is not only compromised, as evidenced by the P300 and MoCA tests, but also affected with increase the severity of COVID-19 infection.