Overconsumption of instant noodles (IND) has recently received special attention, owing to its association with obesity and the cardiometabolic syndrome. Curcumin (CUR) exhibit cellular activity, supporting its numerous health advantages due to its anti-inflammatory and antioxidant effects. This study was performed to evaluate the ameliorative effect of oral administration of CUR or curcumin nanoparticles (CUR-NPs) in IND-fed rats. Forty male rats were separated into four groups of ten rats each, these groups were control (GTRL), IND, IND + CUR and IND + CUR-NPs groups. The IND- fed group showed a significant decrease in RBC count, HB, HCT, MCV and PLT with a significant increase in WBC count and neutrophils percentage. A significant reduction in the serum levels of total testosterone (Tt) and luteinizing hormone (LH) but a non- significant change in follicle-stimulating hormone (FSH) levels in IND- fed group. The testicular tissue from the IND-fed group exhibits remarkable degenerative changes in spermatogenic series as well as testicular atrophy as showen by reduction in diameter of seminiferous tubules. There was also a marked increase in the collagen fibers and TNF-α-immunostaining. Oral administration of CUR or CUR-NPs to the IND- fed group showed signs of improvement in the previous haematological and the alteration in the structure and function of testis compared to IND- fed group. There was no significant difference in the tested parameters between the CUR and CUR-NPs effect.