Background: Nurses play an integral role in caring for patients with bleeding disorders, assist in developing a comprehensive nursing care plan and implementing appropriate interventions for patients at risk for bleeding by considering their unique needs and promoting their overall well-being, nursing can provide optimal care. Aim: this study aimed to assess the effect of using Risk for Bleeding Nursing Training Program on nursing performance. Design a quasi-experimental design was used to conduct this study. Setting: This study was conducted at King Saud Medical City (KSMC), Riyadh, Saudi Arabia. Which is considered as one of the largest in Ministry of Health (MOH) with an occupancy. Sampling: A convenience sample consisted of 77 staff nurses working in Pediatric and Adult Hematology Department. Tools of data collection consisted of three parts Demographic characteristics of nurses, Nurses knowledge about how to assess patient risk for bleeding and Nurses' practices toward patient risk for bleeding. Results: a marked improvement in practices of studied nurses toward patients risk of bleeding with a highly statistical significant difference (p<0.001) between pre and post-intervention phases. Conclusion: the current study concluded that the structured training program significantly enhanced nurses knowledge and adherence to best practices toward patients risk for bleeding. Recommendations: Integrating Risk for Bleeding Training program into routine nursing education can improve patient safety and clinical out comes.