Aim: The loss of mandibular continuity due to tumour ablative surgery can pose challenges ‎at a functional and aesthetic level. The primary concern with rehabilitation is the ‎management of mandibular deviation, which when not corrected surgically, would need ‎prosthetic intervention. Mandibular guidance therapy works in principle by reprogramming ‎the mandible and associated muscles into an acceptable occlusal relationship, conducive to ‎rehabilitation. ‎ Case presentation: This case report discusses two patients: one presenting two weeks post-‎surgery and the other twelve weeks post-surgery. The report highlights the initial condition ‎of the stomatognathic system, the challenges encountered in managing mandibular ‎deviation, and the outcomes achieved through interdisciplinary treatment planning.‎ Conclusion: The outcome of prosthetic intervention post-surgery and subsequent ‎rehabilitation procedures is largely time dependent. In severe deviation with restricted ‎mobility, a holistic approach that includes immediate prosthetic intervention and supportive ‎therapy in the form of joint mobilization exercises is vital in improving mobility of the jaw.‎