Background: Multiple sclerosis disease (MS) is a persistent condition with ongoing inflammation, demyelination, and
neurodegeneration of the central nervous system that impacts around 3 million people globally, experiencing worsening
Physical difficulties and cognitive as well. Patients with multiple sclerosis (PwMS) participate in reduced physical activity,
leading to de-conditioning and a decline in functional ability. Aerobic arm training is easily accessible, has advantages for
PwMS especially in advanced stage and serving as an alternative option in various circumstances.
Objective: This study is intended to emphasize and summarize the main findings about the impact of arm cranking on
fatigue and functional outcomes in patients suffering from multiple sclerosis disease.
Methods: We explored the scientific databases for arm cycling in multiple sclerosis disease. We decided that there will be
no language restriction, no time limitation, only human studies, and only clinical trials studies will be included.
Conclusion: A review of the existing literature determined that employing arm cycling with PwMS acts as a possible
intervention to improve Quality of their Life and the participation in everyday activities, especially when integrated with
conventional rehabilitation methods. The available literature shows that a need for longer treatment time and high-quality
studies to substantiate the evidence-based practice for PwMS.