Background: Understanding patients' perceptions and satisfaction level regarding cardiac catheterization is crucial for identifying knowledge gaps and enhancing the overall quality of care provided in this clinical setting. Aim: To assess perception and satisfaction level of patients undergoing cardiac catheterization. Design: A descriptive research design was used. Sample and setting: the study was conducted in cardiac catheterization units at Assiut general hospital. Sample: A convenient sample of 100 adult patients (male and female) undergoing cardiac catheterization were included in the study. Tools: three main tools were used to collect data include Tool (I): Patient assessment tool (demographic, clinical data and diagnostic tests and Laboratory Investigations). Tool (II) Patient perception assessment tool. Tool (III): Short Assessment Patient Satisfaction (SAPS) tool. Results: The mean age of the studied patients was 55.10 ± 11.12 years, majority of them were males (63%), married (96%), from rural areas (59%). While majority (83%) felt they received complete information about the procedure, A majority (80%) had "unacceptable" perceptions of their care, but overall, most patients reported being satisfied, with no statistically significant difference in satisfaction based on socio demographic factors. Additionally, a significant relationship was found between patient perceptions and education and employment. Conclusion: There was a positive correlation between the patients' perceptions and their satisfaction levels regarding cardiac catheterization. Recommendation: A comprehensive educational program is recommended to address knowledge gaps, enhance communication with healthcare providers, and provide continuous support throughout the patient care.