Chronic kidney disease (CKD) is a serious and widespread  health concern for our feline companions, often dubbed a "silent killer." This label reflects the disease's insidious nature; in its early stages, CKD typically shows no obvious symptoms, making early detection incredibly challenging. This lack of awareness contributes significantly to the high rates of  illness and mortality among cats. Understanding the risk factors for CKD is crucial for proactive pet ownership. Conditions such as advanced age, certain breeds, gender differences, systemic hypertension, cardiovascular issues, and urinary tract infections (UTIs) all play a role in the development of this serious disease. A thorough diagnosis is essential and involves a detailed medical history, comprehensive physical examination including,  body condition assessment and blood pressure evaluation, hematology, serum biochemistry, urinalysis, and advanced imaging techniques. One noteworthy advancement in diagnosing CKD is the use of serum symmetric dimethylarginine (SDMA). This sensitive biomarker allows for earlier detection of kidney dysfunction compared to the traditional serum creatinine test, which can be misleading due to variations in muscle mass. When it comes to managing CKD in cats, a personalized approach is vital. The focus should be on two primary goals: slowing disease progression while preserving remaining kidney function, and improving the cat's quality of life by managing clinical symptoms. It's important to remember that the prognosis for a cat with CKD greatly depends on the stage at which it is diagnosed ; cats in stages I and II generally have a favorable outlook, while those in stages III and IV face a more guarded prognosis.