Objectives: The aim of this study was to conduct a comparison between the efficacy of autologous platelet-rich plasma (PRP) and phytoestrogen vaginal gel in the treatment of stress urinary incontinence (SUI) in postmenopausal women.
Patients and Methods: This prospective randomized clinical study was carried out on 40 post- menopausal women with mild to moderate SUI, positive cough leakage test result, absence of infection and no surgery related to SUI. Two equal sets of cases were formed.: Group I (PRP group): injected with platelet-rich plasma (PRP) at the mid-urethral site on the anterior vaginal wall close to external urethral sphincter and group Ⅱ (Phytoestrogen gel group): received phytoestrogen gel as intravaginal gel.
Results: International consultation on incontinence questionnaire- short form (ICIQ-SF) and incontinence outcome questionnaire (IOQ) were significantly improved after 6 months compared to baseline and in group I (P <0.05). ICIQ-SF, incontinence impact questionnaire (IIQ-7), IOQ, urinary distress inventory (UDI-6) and Overactive Bladder Symptom Scores (OABSS) were significantly lower after 6 months compared to baseline in group I and II (P <0.001). ICIQ-SF, UDI-6 and IIQ-7 were significantly lower after 6 m in Group I than in Group II (P<0.05). The success rate was significantly higher in group I than in group II (P =0.027).
Conclusions: In menopausal women with SUI, the repeated PRP injection was more effective and safer in alleviating SUI than phytoestrogen gel.