Aim: This clinical trial was conducted to compare the clinical performance of bioactive self-adhering flowable composite versus nanohybrid composite resin with a universal adhesive in total etch mode for restoring carious cervical lesions over one year follow-up period.
Materials and Methods: A randomized clinical trial was conducted on 36 patients who had carious cervical lesions in anterior and posterior teeth. Participants were randomly allocated into two groups (n=18 for each group) in which they received, either; FIT SA F03 (bioactive SAFC), or Neo Spectra™ ST HV (nanohybrid composite resin) with using universal adhesive (Prime&Bond universal™) in a total etch mode. All materials were applied according to manufacturers' instructions. Restorations were evaluated at baseline (one week), after three, six, and 12 months by two blinded assessors using modified USPHS criteria measuring (cavosurface marginal discoloration, marginal integrity, post-operative hypersensitivity, gross fracture and retention, surface texture, color match, anatomic contour, and secondary caries).
Results: Intergroup comparison between both materials has shown no statistically significant difference within different follow up periods; baseline, three, six and 12 months respectively. There was no difference between both materials in restoration of carious cervical lesions after 12 months.

Conclusion: Bioactive SAFC and nanohybrid composite resin have shown satisfactory clinical performance in restoring carious cervical lesions after 12 months of follow up. Also, bioactive SAFC restorations could be of clinical value in treating caries control cases with respect to its ionic discharging property.