Nano fertilisers significantly enhance crop growth, yield, and quality parameters in agriculture, enhancing nutrient use efficiency. The present study investigated the effect of NPK nano-fertilisers' foliar application on the attributes and yield of two wheat genotypes in semi-arid land conditions of North Sinai. The experiment was laid out in a split-split plot design within a randomized complete block design with three replications. An area of 240 m² was plowed and divided into two blocks for each wheat genotype, Sakha-95 and Ismalia-1 (main plots). The sub-plots were assigned to the different nano NPK foliar spray fertilization treatments coupled with varying percentages of conventional fertilization, as follows: T1: 100% conventional fertilization (control); T2: a foliar spray of nano NPK + 10% conventional NPK; T3: a foliar spray of nano NPK + 25% conventional NPK; T4: a foliar spray of nano NPK + 50% conventional NPK; T5: a foliar spray of nano NPK + 75% conventional NPK. The measured yield parameters were plant height (cm), number of spikes/m2, number of spikelets, number of tillers/m2, spike length (cm), number of kernels /spike, 100-grain weight (g), biological yield (ton/fed), grain yield (ton/fed) and harvest index(%). The results revealed that Ismalia-1 under 75% conventional NPK coupled with nano NPK foliar spray application at two ml/l was the superior practice for increasing all studied traits.